INFLUENCE OF PHENYLALANINE ANALOGUES UPON BACTERIAL ACCUMULATION AND INCORPORATION OF PHENYLALANINE

Influence of phenylalanine analogues upon bacterial accumulation and incorporation of phenylalanine.

Conway, T. W. (The University of Texas, Austin), E. M. Lansford, Jr., and W. Shive. Influence of phenylalanine analogues upon bacterial accumulation and incorporation of phenylalanine. J. Bacteriol. 85:141-149. 1963.-Phenylalanine accumulation and its relation to phenylalanine incorporation into trichloroacetic acid-insoluble material in Escherichia coli 9723 were studied with a variety of stru...

Bacterial phenylalanine and phenylacetate catabolic pathway revealed.

Aromatic compounds constitute the second most abundant class of organic substrates and environmental pollutants, a substantial part of which (e.g., phenylalanine or styrene) is metabolized by bacteria via phenylacetate. Surprisingly, the bacterial catabolism of phenylalanine and phenylacetate remained an unsolved problem. Although a phenylacetate metabolic gene cluster had been identified, the ...

Mechanism of phenylalanine regulation of phenylalanine hydroxylase.

The mechanism of phenylalanine regulation of rat liver phenylalanine hydroxylase was studied. We show that phenylalanine "activates" phenylalanine hydroxylase, converting it from an inactive to active form, by binding at a true allosteric regulatory site. One phenylalanine molecule binds per enzyme subunit; it remains at this site during catalytic turnover and, while there, cannot be hydroxylat...

Growth Inhibition of Tubercle Bacilli by Analogues of Phenylalanine.

Many studies have been devoted to the inhibitory action of various metabolite analogues on microbial growth. In most of this work, however, such nonpathogens as the yeasts, lactobacilli, and Escherichia coli have served as the test organism and there has been little attempt to correlate or extend the studies to pathogenic bacteria, especially those organisms synthesizing their own growth factor...

Genetic Incorporation of Seven ortho-Substituted Phenylalanine Derivatives